Oxidative stress can lead to cellular senescence, in a p53-dependent pathway. Bach1, a transcription factor that regulates the response to oxidative stress, is now shown to inhibit senescence induced by high oxygen concentrations or by Ras. Bach1 is recruited to a subset of p53 target genes and promotes histone deacetylation thereby impeding p53 action.

The interactome of eukaryotic chaperonin TRiC/CCT is identified through a genome-wide approach, revealing enrichment in large, multidomain proteins, or components of multimeric complexes, rich in hydrophobic sequences and with high β-sheet propensity. Thus, TRiC substrates are slow-folding proteins with complex topology, which are likely to be more prone to aggregation.

A window onto the world of protein structure has opened with the new, freely accessible PSI-Nature Structural Genomics Knowledgebase. The site is designed to turn the products of the Protein Structure Initiative into knowledge that is important for understanding living systems and disease, complemented with structural biology updates from Nature Publishing Group.

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