Nature Reviews Immunology
Volume 8, No 11 November 2008
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2007 ISI Impact Factor 28.3(*Source of Impact Factor data)
ADVANCE ONLINE PUBLICATION
Review
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
Pärt Peterson, Tõnis Org & Ana Rebane
This Review focuses on the structural domains of the autoimmune regulator (AIRE) protein, its nuclear localization, and its role in histone binding and transcriptional elongation, which help to explain the crucial involvement of AIRE in the negative selection of T cells in the thymus.
ADVANCE ONLINE PUBLICATION
Perspective
Immunotherapy of autoimmunity and cancer: the penalty for success
Rachel R. Caspi
Immunotherapy for cancer sometimes has autoimmune complications, and immunotherapy for autoimmunity can compromise microbial defence and immunosurveillance. In this article, Rachel Caspi explores the potential penalties of successful immunotherapeutic approaches and highlights the need for more specific modalities.
ADVANCE ONLINE PUBLICATION
Review
Viral evasion and subversion of pattern–recognition receptor signalling
Andrew G. Bowie & Leonie Unterholzner
This Review highlights how understanding the mechanisms by which viruses evade and subvert host signalling by pattern–recognition receptors has provided insights into the function of these signalling pathways, the host proteins that are involved and ways in which the pathways might be manipulated therapeutically.
CURRENT ISSUE
Perspective
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases
David S. Schneider & Janelle S. Ayres
These authors express their opinion that we should devote more research attention to uncovering the mechanisms by which a host can tolerate, as well as resist, infection with a pathogen. New drugs to increase tolerance to infection should provide therapies to which pathogens will not develop resistance.
CURRENT ISSUE
Progress
Cytokine–mediated regulation of antimicrobial proteins
Jay K. Kolls, Paul B. McCray, Jr & Yvonne R. Chan
Antimicrobial proteins are an ancient mechanism of defence against pathogens at skin and mucosal surfaces. As discussed in this Progress article, new studies identify dynamic cross–regulation between cytokines and antimicrobial peptides, which contributes to immunity and homeostasis at these sites.
CURRENT ISSUE
Research Highlights
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HIV:
Learning from a monkey!
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Mucosal immunology:
Mismanaged ER stress and inflammation
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Autoimmunity:
Balancing B–cell subsets in EAE
More Immunology
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Signaling Gateway
The free one-stop resource for all cell-signalling researchers
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Immunology@nature.com
More articles on immunology, from the Nature Publishing Group
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Cell Migration Gateway
The definitive online resource for all the latest developments in cell migration
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Immunology Conferences
A calendar of forthcoming meetings and workshops from across the field of immunology.
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Nature Reports Avian Flu
The latest research news, comments and analysis on avian flu
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Recommended Links
Links recommended by the editors
Noticeboard
Article series on Tissue–specific immune responses
In October 2008, Nature Reviews Immunology begin a series of articles related to tissue–specific immune responses. These articles will consider aspects of immune responses in the context of the tissue in which they occur and highlight how tissue cells or tissue–derived factors in different organs can shape the outcome of these responses.
Structural Genomics Knowledgebase
A new window onto the world of protein structure has opened with the new, free PSI–Nature Structural Genomics Knowledgebase (PSI–SGKB). The site makes available the research data and tools from the Protein Structure Initiative, complemented with structural biology updates from NPG. Users can also suggest proteins for structure analysis.
Focus on Dendritic Cells
This Focus from Immunology & Cell Biology presents a collection of review and research articles that outline our current understanding of DC heterogeneity, how different populations contribute to T–cell responses, and how T cells differentiate and maintain functional diversity.
Focus on Leukocyte Trafficking
This Focus from Nature Immunology presents five specially commissioned reviews and an overview that discuss how immune cells traffic through tissues and lymphoid organs.
Nature Reviews Genetics Wiki
Nature Reviews Genetics presents a first for Nature Publishing Group — a Review that can be commented on, updated, and added to by readers using Wiki features. The Review explores the past, present and future of the biology cyberinfrastructure.
Focus on Mucosal Immunology
This Focus from Nature Reviews Immunology highlights the latest advances in our understanding of host–microbe interactions at mucosal sites and the consequences of immune dysregulation at these sites.
Focus on Natural Killer Cells
Nature Immunology presents a series of specially commissioned articles that focus on the differentiation, responsiveness and biological roles of natural killer cells. The focus is available free to registrants for 6 months.
Focus on Allergy and Asthma
Millions of people worldwide suffer from respiratory diseases such as allergies, asthma and chronic obstructive pulmonary disease, and these diseases constitute a major public health burden. This Focus issue highlights the latest advances in our understanding of the immune bases of these diseases and outlines how this knowledge can be translated into more effective treatment strategies.
Poster on innate immunity: sensing and signalling
This poster provides an overview of the components and networks involved in pathogen sensing and signalling in the innate immune system. The poster is freely available thanks to support from MedImmune.
Web Focuses
Please visit our Web Focuses, which provide a selection of articles on a related theme drawn from Nature Publishing Group on key current topics of immunology.
Posters
Our Posters provide a visual overview of a hot topic in immunology. Thanks to generous support, they are freely available and can be viewed online as a high–resolution PDF.
Journal Citation Reports, Thomson, 2007