Nature Clinical Practice Endocrinology & Metabolism Nature Clinical Practice Endocrinology & Metabolism provides physicians with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpendmet/current_issue/ Nature Publishing Group en © Nature Publishing Group Nature Clinical Practice Endocrinology & Metabolism 1745-8366 1745-8374 © Nature Publishing Group permissions@nature.com Nature Clinical Practice Endocrinology & Metabolism http://www.nature.com/includes/rj_globnavimages/ncpendmet_logo.gif http://www.nature.com/ncpendmet/ Pregabalin for painful diabetic peripheral neuropathy http://dx.doi.org/10.1038/ncpendmet1019 Pregabalin for painful diabetic peripheral neuropathy

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1019

Authors: Lee C Rogers & David G Armstrong

]]> Pregabalin for painful diabetic peripheral neuropathy Lee C Rogers David G Armstrong doi:10.1038/ncpendmet1019 Nature Clinical Practice Endocrinology & Metabolism 2008-11-18 Nature Clinical Practice Endocrinology & Metabolism 2008-11-18 Practice Point Colesevelam improves glycemic control and lipid management in inadequately controlled type 2 diabetes mellitus http://dx.doi.org/10.1038/ncpendmet1021 Colesevelam improves glycemic control and lipid management in inadequately controlled type 2 diabetes mellitus

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1021

Authors: Konstantinos Tziomalos, Vasilios G Athyros & Dimitri P Mikhailidis

]]> Colesevelam improves glycemic control and lipid management in inadequately controlled type 2 diabetes mellitus Konstantinos Tziomalos Vasilios G Athyros Dimitri P Mikhailidis doi:10.1038/ncpendmet1021 Nature Clinical Practice Endocrinology & Metabolism 2008-11-18 Nature Clinical Practice Endocrinology & Metabolism 2008-11-18 Practice Point Should serial assessment of bone turnover markers be included in fracture risk calculation in elderly women? http://dx.doi.org/10.1038/ncpendmet1018 Should serial assessment of bone turnover markers be included in fracture risk calculation in elderly women?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1018

Author: Samuel D Vasikaran

]]> Should serial assessment of bone turnover markers be included in fracture risk calculation in elderly women? Samuel D Vasikaran doi:10.1038/ncpendmet1018 Nature Clinical Practice Endocrinology & Metabolism 2008-11-18 Nature Clinical Practice Endocrinology & Metabolism 2008-11-18 Practice Point Routine screening for germline RET mutations is recommended for all patients with medullary thyroid cancer http://dx.doi.org/10.1038/ncpendmet1020 Routine screening for germline RET mutations is recommended for all patients with medullary thyroid cancer

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1020

Authors: Diana L Learoyd & Bruce G Robinson

]]> Routine screening for germline RET mutations is recommended for all patients with medullary thyroid cancer Diana L Learoyd Bruce G Robinson doi:10.1038/ncpendmet1020 Nature Clinical Practice Endocrinology & Metabolism 2008-11-11 Nature Clinical Practice Endocrinology & Metabolism 2008-11-11 Practice Point Is twice-yearly denosumab beneficial in postmenopausal women with osteopenia but no history of fracture? http://dx.doi.org/10.1038/ncpendmet0981 Is twice-yearly denosumab beneficial in postmenopausal women with osteopenia but no history of fracture?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0981

Author: Sherri-Ann M Burnett-Bowie

]]> Is twice-yearly denosumab beneficial in postmenopausal women with osteopenia but no history of fracture? Sherri-Ann M Burnett-Bowie doi:10.1038/ncpendmet0981 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Practice Point Does vitamin D3 dosing schedule influence treatment efficacy in nursing home residents with vitamin D deficiency? http://dx.doi.org/10.1038/ncpendmet0979 Does vitamin D3 dosing schedule influence treatment efficacy in nursing home residents with vitamin D deficiency?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0979

Author: Michael F Holick

]]> Does vitamin D3 dosing schedule influence treatment efficacy in nursing home residents with vitamin D deficiency? Michael F Holick doi:10.1038/ncpendmet0979 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Practice Point Is glucose normalization an evidence-based treatment for patients with type 2 diabetes mellitus? http://dx.doi.org/10.1038/ncpendmet0997 Is glucose normalization an evidence-based treatment for patients with type 2 diabetes mellitus?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0997

Authors: Lars Rydén, Klas Malmberg & Linda Mellbin

]]> Is glucose normalization an evidence-based treatment for patients with type 2 diabetes mellitus? Lars Rydén Klas Malmberg Linda Mellbin doi:10.1038/ncpendmet0997 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Practice Point Does serum TSH level have thyroid hormone independent effects on bone turnover? http://dx.doi.org/10.1038/ncpendmet1004 Does serum TSH level have thyroid hormone independent effects on bone turnover?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1004

Author: Graham R Williams

]]> Does serum TSH level have thyroid hormone independent effects on bone turnover? Graham R Williams doi:10.1038/ncpendmet1004 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Practice Point Vertebral fracture assessment using standard bone densitometry equipment predicts incident fractures in women http://dx.doi.org/10.1038/ncpendmet0984 Vertebral fracture assessment using standard bone densitometry equipment predicts incident fractures in women

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0984

Authors: Mary L Bouxsein & Pierre D Delmas

]]> Vertebral fracture assessment using standard bone densitometry equipment predicts incident fractures in women Mary L Bouxsein Pierre D Delmas doi:10.1038/ncpendmet0984 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 Practice Point Could renin inhibition be the next step forward in the treatment of diabetic kidney disease? http://dx.doi.org/10.1038/ncpendmet0983 Could renin inhibition be the next step forward in the treatment of diabetic kidney disease?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0983

Author: Katherine R Tuttle

]]> Could renin inhibition be the next step forward in the treatment of diabetic kidney disease? Katherine R Tuttle doi:10.1038/ncpendmet0983 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 Practice Point Should the levothyroxine starting dose be tailored to disease severity in neonates with congenital hypothyroidism? http://dx.doi.org/10.1038/ncpendmet0970 Should the levothyroxine starting dose be tailored to disease severity in neonates with congenital hypothyroidism?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0970

Author: Stephen H LaFranchi

]]> Should the levothyroxine starting dose be tailored to disease severity in neonates with congenital hypothyroidism? Stephen H LaFranchi doi:10.1038/ncpendmet0970 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 Practice Point Is megestrol acetate a suitable option for treatment of hot flashes in women with breast cancer? http://dx.doi.org/10.1038/ncpendmet0977 Is megestrol acetate a suitable option for treatment of hot flashes in women with breast cancer?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0977

Author: Michelle P Warren

]]> Is megestrol acetate a suitable option for treatment of hot flashes in women with breast cancer? Michelle P Warren doi:10.1038/ncpendmet0977 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 Practice Point Metformin therapy for gestational diabetes mellitus: are we there yet? http://dx.doi.org/10.1038/ncpendmet0969 Metformin therapy for gestational diabetes mellitus: are we there yet?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0969

Author: Denice S Feig

]]> Metformin therapy for gestational diabetes mellitus: are we there yet? Denice S Feig doi:10.1038/ncpendmet0969 Nature Clinical Practice Endocrinology & Metabolism 2008-09-23 Nature Clinical Practice Endocrinology & Metabolism 2008-09-23 Practice Point Inhaled insulin—what went wrong http://dx.doi.org/10.1038/ncpendmet1007 FDA approval of inhaled insulin offered the possibility of a new direction in diabetes care. Nonetheless, within a year of coming to market, the first inhaled insulin product was withdrawn by the manufacturer. Here, Mitri and Pittas examine the factors behind the failure of inhaled insulin to be adopted by patients and clinicians. Inhaled insulin—what went wrong

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1007

Authors: Joanna Mitri & Anastassios G Pittas

]]> Inhaled insulin—what went wrong Joanna Mitri Anastassios G Pittas doi:10.1038/ncpendmet1007 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Viewpoint The role of antipsychotic agents in the development of diabetes mellitus http://dx.doi.org/10.1038/ncpendmet1001 Use of the second-generation (atypical) antipsychotic agents has led to concerns about possible adverse metabolic effects, including an increased risk of diabetes mellitus. The potential mechanisms underlying treatment-emergent diabetes mellitus, and strategies for effective management of affected individuals, are explored by the author of this Viewpoint. The role of antipsychotic agents in the development of diabetes mellitus

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1001

Author: Samuel Dagogo-Jack

]]> The role of antipsychotic agents in the development of diabetes mellitus Samuel Dagogo-Jack doi:10.1038/ncpendmet1001 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Nature Clinical Practice Endocrinology & Metabolism 2008-10-28 Viewpoint Endoscopic surgery for cystic lesions of the pituitary region http://dx.doi.org/10.1038/ncpendmet0975 Cystic lesions of the pituitary region are quite common but present a challenge for diagnosis and treatment. Several types of cystic lesion are recognized, including cystic pituitary adenomas, Rathke cleft cysts, arachnoid cysts, and craniopharyngiomas. The clinical symptoms and diagnosis of these lesions, and the use of endoscopy for surgical intervention, are discussed in this Viewpoint. Endoscopic surgery for cystic lesions of the pituitary region

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0975

Author: Edward R Laws

]]> Endoscopic surgery for cystic lesions of the pituitary region Edward R Laws doi:10.1038/ncpendmet0975 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 Viewpoint Insulin therapy versus cell-based therapy for type 1 diabetes mellitus: what lies ahead? http://dx.doi.org/10.1038/ncpendmet0971 Current approaches to treat type 1 diabetes mellitus can be divided into three categories: insulin therapy, cell-based therapy and modification of the autoimmune process associated with type 1 diabetes mellitus. Comparing the benefits, risk and challenges of insulin therapy and cell-based therapy, the author of this Viewpoint discusses the prospects for these two therapeutic approaches. Insulin therapy versus cell-based therapy for type 1 diabetes mellitus: what lies ahead?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0971

Author: Alvin C Powers

]]> Insulin therapy versus cell-based therapy for type 1 diabetes mellitus: what lies ahead? Alvin C Powers doi:10.1038/ncpendmet0971 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 Viewpoint Ghrelin as a pleotrophic modulator of gonadal function and reproduction http://dx.doi.org/10.1038/ncpendmet1003 The gut hormone ghrelin is a putative signal of energy balance. In addition, ghrelin might act as a pleotrophic modulator of reproductive function. The experimental and clinical data that support a role for ghrelin in the hypothalamic–pituitary–gonadal axis are summarized by the author of this Review. Ghrelin as a pleotrophic modulator of gonadal function and reproduction

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1003

Author: Manuel Tena-Sempere

]]> Ghrelin as a pleotrophic modulator of gonadal function and reproduction Manuel Tena-Sempere doi:10.1038/ncpendmet1003 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Review Treating fetal thyroid and adrenal disorders through the mother http://dx.doi.org/10.1038/ncpendmet1005 As genetic and imaging techniques advance, more is becoming known about the nature of various fetal disorders. Some of these disorders may be treated, with varying degrees of success, through the mother. This Review presents information particularly on fetal adrenal and thyroid disorders and discusses the various management approaches and their related risks and outcomes. Treating fetal thyroid and adrenal disorders through the mother

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet1005

Authors: Guy Van Vliet, Michel Polak & E Martin Ritzén

]]> Treating fetal thyroid and adrenal disorders through the mother Guy Van Vliet Michel Polak E Martin Ritzén doi:10.1038/ncpendmet1005 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Review Mechanisms related to the pathophysiology and management of central hypothyroidism http://dx.doi.org/10.1038/ncpendmet0995 The prevalence of central hypothyroidism is unknown, but might be greater than reported. This disorder may arise from a variety of causes, from tumor-related hormonal disturbances, to mechanical problems related to traumatic brain injury, to being induced by drug therapy. This Review presents an overview of etiologies, diagnosis and management. Mechanisms related to the pathophysiology and management of central hypothyroidism

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0995

Authors: Masanobu Yamada & Masatomo Mori

]]> Mechanisms related to the pathophysiology and management of central hypothyroidism Masanobu Yamada Masatomo Mori doi:10.1038/ncpendmet0995 Nature Clinical Practice Endocrinology & Metabolism 2008-10-21 Nature Clinical Practice Endocrinology & Metabolism 2008-10-21 Review Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9 http://dx.doi.org/10.1038/ncpendmet0980 Aquaporin subtypes 7 and 9 have vital roles in the control of glycerol channels in adipocytes and hepatocytes, and thereby the balance between glycerol release and uptake by adipocytes and the liver, respectively. This Review discusses the pathophysiological importance of these channels in obesity and related disorders. Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0980

Authors: Norikazu Maeda, Tohru Funahashi & Iichiro Shimomura

]]> Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9 Norikazu Maeda Tohru Funahashi Iichiro Shimomura doi:10.1038/ncpendmet0980 Nature Clinical Practice Endocrinology & Metabolism 2008-10-14 Nature Clinical Practice Endocrinology & Metabolism 2008-10-14 Review A patient with ectopic cortisol production derived from malignant testicular masses http://dx.doi.org/10.1038/ncpendmet0985 This article describes a patient with Cushing syndrome presumably attributable to an adrenocortical carcinoma arising from testicular adrenal rest cells. The authors discuss treatment options for adrenocorticotropic hormone-independent hypercortisolism and highlight the difficulties in determining the origin of ectopic cortisol production. A patient with ectopic cortisol production derived from malignant testicular masses

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0985

Authors: Shilpa H Jain, Peter M Sadow, Vania Nosé & Robert G Dluhy

]]> A patient with ectopic cortisol production derived from malignant testicular masses Shilpa H Jain Peter M Sadow Vania Nosé Robert G Dluhy doi:10.1038/ncpendmet0985 Nature Clinical Practice Endocrinology & Metabolism 2008-10-21 Nature Clinical Practice Endocrinology & Metabolism 2008-10-21 Case Study How do detemir and glargine compare when added to oral agents in insulin-naïve patients with type 2 diabetes mellitus? http://dx.doi.org/10.1038/ncpendmet0998 How do detemir and glargine compare when added to oral agents in insulin-naïve patients with type 2 diabetes mellitus?

Nature Clinical Practice Endocrinology & Metabolism. doi:10.1038/ncpendmet0998

Author: Jennifer B Marks

]]> How do detemir and glargine compare when added to oral agents in insulin-naïve patients with type 2 diabetes mellitus? Jennifer B Marks doi:10.1038/ncpendmet0998 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Nature Clinical Practice Endocrinology & Metabolism 2008-11-04 Corrigendum