Nature Clinical Practice Endocrinology & Metabolism Nature Clinical Practice Endocrinology & Metabolism provides physicians with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpendmet/current_issue/ Nature Publishing Group en © 2008 Nature Publishing Group Nature Clinical Practice Endocrinology & Metabolism 1745-8366 1745-8374 © 2008 Nature Publishing Group permissions@nature.com Nature Clinical Practice Endocrinology & Metabolism http://www.nature.com/includes/rj_globnavimages/ncpendmet_logo.gif http://www.nature.com/ncpendmet/ Endocrinology and oncology: closer ties will be mutually beneficial http://dx.doi.org/10.1038/ncpendmet0974 Endocrinology and oncology: closer ties will be mutually beneficial

Nature Clinical Practice Endocrinology & Metabolism 4, 585 (2008). doi:10.1038/ncpendmet0974

Author: P Reed Larsen

]]> Endocrinology and oncology: closer ties will be mutually beneficial P Reed Larsen doi:10.1038/ncpendmet0974 Nature Clinical Practice Endocrinology & Metabolism 4, 585 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Editorial 585 585 Hearing loss is an under-recognized complication of diabetes mellitus http://dx.doi.org/10.1038/ncpendmet0956 Hearing loss is an under-recognized complication of diabetes mellitus

Nature Clinical Practice Endocrinology & Metabolism 4, 586 (2008). doi:10.1038/ncpendmet0956

]]> Hearing loss is an under-recognized complication of diabetes mellitus doi:10.1038/ncpendmet0956 Nature Clinical Practice Endocrinology & Metabolism 4, 586 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 586 586 Variable suppression of TSH by human chorionic gonadotropin during early pregnancy http://dx.doi.org/10.1038/ncpendmet0957 Variable suppression of TSH by human chorionic gonadotropin during early pregnancy

Nature Clinical Practice Endocrinology & Metabolism 4, 586 (2008). doi:10.1038/ncpendmet0957

]]> Variable suppression of TSH by human chorionic gonadotropin during early pregnancy doi:10.1038/ncpendmet0957 Nature Clinical Practice Endocrinology & Metabolism 4, 586 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 586 586 Dementia in elderly people with diabetes is predicted by microalbuminuria http://dx.doi.org/10.1038/ncpendmet0958 Dementia in elderly people with diabetes is predicted by microalbuminuria

Nature Clinical Practice Endocrinology & Metabolism 4, 586 (2008). doi:10.1038/ncpendmet0958

]]> Dementia in elderly people with diabetes is predicted by microalbuminuria doi:10.1038/ncpendmet0958 Nature Clinical Practice Endocrinology & Metabolism 4, 586 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 586 587 Contribution of genetic factors to type 1 diabetes has changed but not decreased http://dx.doi.org/10.1038/ncpendmet0959 Contribution of genetic factors to type 1 diabetes has changed but not decreased

Nature Clinical Practice Endocrinology & Metabolism 4, 587 (2008). doi:10.1038/ncpendmet0959

]]> Contribution of genetic factors to type 1 diabetes has changed but not decreased doi:10.1038/ncpendmet0959 Nature Clinical Practice Endocrinology & Metabolism 4, 587 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 587 587 Urban air pollution is a risk factor for vitamin D deficiency in postmenopausal women http://dx.doi.org/10.1038/ncpendmet0960 Urban air pollution is a risk factor for vitamin D deficiency in postmenopausal women

Nature Clinical Practice Endocrinology & Metabolism 4, 587 (2008). doi:10.1038/ncpendmet0960

]]> Urban air pollution is a risk factor for vitamin D deficiency in postmenopausal women doi:10.1038/ncpendmet0960 Nature Clinical Practice Endocrinology & Metabolism 4, 587 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 587 587 Serum TRACP5b might be a good marker for bone resorption in chronic kidney disease http://dx.doi.org/10.1038/ncpendmet0962 Serum TRACP5b might be a good marker for bone resorption in chronic kidney disease

Nature Clinical Practice Endocrinology & Metabolism 4, 588 (2008). doi:10.1038/ncpendmet0962

]]> Serum TRACP5b might be a good marker for bone resorption in chronic kidney disease doi:10.1038/ncpendmet0962 Nature Clinical Practice Endocrinology & Metabolism 4, 588 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 588 588 Evaluation of insulin sensitivity and β-cell function after gestational diabetes mellitus http://dx.doi.org/10.1038/ncpendmet0963 Evaluation of insulin sensitivity and β-cell function after gestational diabetes mellitus

Nature Clinical Practice Endocrinology & Metabolism 4, 588 (2008). doi:10.1038/ncpendmet0963

]]> Evaluation of insulin sensitivity and β-cell function after gestational diabetes mellitus doi:10.1038/ncpendmet0963 Nature Clinical Practice Endocrinology & Metabolism 4, 588 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 588 588 Maternal thyroid hypofunction does not increase the risk of adverse pregnancy outcomes http://dx.doi.org/10.1038/ncpendmet0964 Maternal thyroid hypofunction does not increase the risk of adverse pregnancy outcomes

Nature Clinical Practice Endocrinology & Metabolism 4, 588 (2008). doi:10.1038/ncpendmet0964

]]> Maternal thyroid hypofunction does not increase the risk of adverse pregnancy outcomes doi:10.1038/ncpendmet0964 Nature Clinical Practice Endocrinology & Metabolism 4, 588 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 588 589 Suppression of p75 neurotrophin receptor aids vascular recovery in diabetic mice http://dx.doi.org/10.1038/ncpendmet0961 Suppression of p75 neurotrophin receptor aids vascular recovery in diabetic mice

Nature Clinical Practice Endocrinology & Metabolism 4, 589 (2008). doi:10.1038/ncpendmet0961

]]> Suppression of p75 neurotrophin receptor aids vascular recovery in diabetic mice doi:10.1038/ncpendmet0961 Nature Clinical Practice Endocrinology & Metabolism 4, 589 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Research Highlights 589 589 Does exposure to childhood radiation influence the development of thyroid nodular disease and thyroid cancer risk? http://dx.doi.org/10.1038/ncpendmet0952 Does exposure to childhood radiation influence the development of thyroid nodular disease and thyroid cancer risk?

Nature Clinical Practice Endocrinology & Metabolism 4, 590 (2008). doi:10.1038/ncpendmet0952

Author: Erik K Alexander

]]> Does exposure to childhood radiation influence the development of thyroid nodular disease and thyroid cancer risk? Erik K Alexander doi:10.1038/ncpendmet0952 Nature Clinical Practice Endocrinology & Metabolism 4, 590 (2008) 2008-09-16 Nature Clinical Practice Endocrinology & Metabolism 2008-09-16 4 11 Practice Point 590 591 Does radiosurgery have a role in the treatment of acromegaly? http://dx.doi.org/10.1038/ncpendmet0948 Does radiosurgery have a role in the treatment of acromegaly?

Nature Clinical Practice Endocrinology & Metabolism 4, 592 (2008). doi:10.1038/ncpendmet0948

Authors: Brooke Swearingen & Jay Loeffler

]]> Does radiosurgery have a role in the treatment of acromegaly? Brooke Swearingen Jay Loeffler doi:10.1038/ncpendmet0948 Nature Clinical Practice Endocrinology & Metabolism 4, 592 (2008) 2008-09-02 Nature Clinical Practice Endocrinology & Metabolism 2008-09-02 4 11 Practice Point 592 593 Is radioiodine more likely than antithyroid drugs to worsen ophthalmopathy in patients with Graves disease? http://dx.doi.org/10.1038/ncpendmet0955 Is radioiodine more likely than antithyroid drugs to worsen ophthalmopathy in patients with Graves disease?

Nature Clinical Practice Endocrinology & Metabolism 4, 594 (2008). doi:10.1038/ncpendmet0955

Author: Rebecca S Bahn

]]> Is radioiodine more likely than antithyroid drugs to worsen ophthalmopathy in patients with Graves disease? Rebecca S Bahn doi:10.1038/ncpendmet0955 Nature Clinical Practice Endocrinology & Metabolism 4, 594 (2008) 2008-08-26 Nature Clinical Practice Endocrinology & Metabolism 2008-08-26 4 11 Practice Point 594 595 Does growth hormone therapy benefit body composition and glucose homeostasis in girls with Turner syndrome? http://dx.doi.org/10.1038/ncpendmet0954 Does growth hormone therapy benefit body composition and glucose homeostasis in girls with Turner syndrome?

Nature Clinical Practice Endocrinology & Metabolism 4, 596 (2008). doi:10.1038/ncpendmet0954

Author: Janet Lo

]]> Does growth hormone therapy benefit body composition and glucose homeostasis in girls with Turner syndrome? Janet Lo doi:10.1038/ncpendmet0954 Nature Clinical Practice Endocrinology & Metabolism 4, 596 (2008) 2008-08-26 Nature Clinical Practice Endocrinology & Metabolism 2008-08-26 4 11 Practice Point 596 597 Is universal screening for thyroid disease in pregnancy a cost-effective strategy? http://dx.doi.org/10.1038/ncpendmet0951 Is universal screening for thyroid disease in pregnancy a cost-effective strategy?

Nature Clinical Practice Endocrinology & Metabolism 4, 598 (2008). doi:10.1038/ncpendmet0951

Authors: Alex Stagnaro-Green & Alan Schwartz

]]> Is universal screening for thyroid disease in pregnancy a cost-effective strategy? Alex Stagnaro-Green Alan Schwartz doi:10.1038/ncpendmet0951 Nature Clinical Practice Endocrinology & Metabolism 4, 598 (2008) 2008-09-02 Nature Clinical Practice Endocrinology & Metabolism 2008-09-02 4 11 Practice Point 598 599 Latent autoimmune diabetes in adults: the search for interventions continues http://dx.doi.org/10.1038/ncpendmet0949 Latent autoimmune diabetes in adults: the search for interventions continues

Nature Clinical Practice Endocrinology & Metabolism 4, 600 (2008). doi:10.1038/ncpendmet0949

Author: Jay S Skyler

]]> Latent autoimmune diabetes in adults: the search for interventions continues Jay S Skyler doi:10.1038/ncpendmet0949 Nature Clinical Practice Endocrinology & Metabolism 4, 600 (2008) 2008-09-02 Nature Clinical Practice Endocrinology & Metabolism 2008-09-02 4 11 Practice Point 600 601 Can the fractional excretion of uric acid distinguish the etiology of hyponatremia in patients taking diuretics? http://dx.doi.org/10.1038/ncpendmet0973 Can the fractional excretion of uric acid distinguish the etiology of hyponatremia in patients taking diuretics?

Nature Clinical Practice Endocrinology & Metabolism 4, 602 (2008). doi:10.1038/ncpendmet0973

Author: Theodore I Steinman

]]> Can the fractional excretion of uric acid distinguish the etiology of hyponatremia in patients taking diuretics? Theodore I Steinman doi:10.1038/ncpendmet0973 Nature Clinical Practice Endocrinology & Metabolism 4, 602 (2008) 2008-09-23 Nature Clinical Practice Endocrinology & Metabolism 2008-09-23 4 11 Practice Point 602 603 Moving towards the use of targeted therapies in thyroid cancer http://dx.doi.org/10.1038/ncpendmet0944 Treatment of thyroid cancer has not changed substantially for many years; however, few effective therapies are available for tumors that are metastatic or unable to take up radioiodine. The author of this Viewpoint, therefore, argues for the need to increase individual treatment efficacy through the introduction of novel targeted therapies. Moving towards the use of targeted therapies in thyroid cancer

Nature Clinical Practice Endocrinology & Metabolism 4, 604 (2008). doi:10.1038/ncpendmet0944

Author: Christopher J McCabe

]]> Moving towards the use of targeted therapies in thyroid cancer Christopher J McCabe doi:10.1038/ncpendmet0944 Nature Clinical Practice Endocrinology & Metabolism 4, 604 (2008) 2008-08-26 Nature Clinical Practice Endocrinology & Metabolism 2008-08-26 4 11 Viewpoint 604 605 Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus? http://dx.doi.org/10.1038/ncpendmet0946 Some studies have reported reduced secretion of glucagon-like peptide-1 (GLP-1) in patients with type 2 diabetes mellitus; however, other studies have failed to find such an association. The evidence for, and against, reduced GLP-1 secretion in the etiology of type 2 diabetes mellitus is debated by the authors of this Viewpoint. Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus?

Nature Clinical Practice Endocrinology & Metabolism 4, 606 (2008). doi:10.1038/ncpendmet0946

Authors: Juris J Meier & Michael A Nauck

]]> Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus? Juris J Meier Michael A Nauck doi:10.1038/ncpendmet0946 Nature Clinical Practice Endocrinology & Metabolism 4, 606 (2008) 2008-08-26 Nature Clinical Practice Endocrinology & Metabolism 2008-08-26 4 11 Viewpoint 606 607 A diagnostic algorithm for the atherogenic apolipoprotein B dyslipoproteinemias http://dx.doi.org/10.1038/ncpendmet0982 The prevalence of atherogenic forms of apolipoprotein B dyslipoproteinemias is high, but effective treatments are available. Quick, accurate diagnosis is, therefore, essential to providing the best care. In this Review an algorithm is proposed to help distinguish between disease subtypes, based on simple parameters that may be measured by low-cost tests widely available in clinical laboratories. A diagnostic algorithm for the atherogenic apolipoprotein B dyslipoproteinemias

Nature Clinical Practice Endocrinology & Metabolism 4, 608 (2008). doi:10.1038/ncpendmet0982

Authors: Jacqueline de Graaf, Patrick Couture & Allan Sniderman

]]> A diagnostic algorithm for the atherogenic apolipoprotein B dyslipoproteinemias Jacqueline de Graaf Patrick Couture Allan Sniderman doi:10.1038/ncpendmet0982 Nature Clinical Practice Endocrinology & Metabolism 4, 608 (2008) 2008-10-07 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 4 11 Review 608 618 Mechanisms of macrophage activation in obesity-induced insulin resistance http://dx.doi.org/10.1038/ncpendmet0976 Macrophages have important roles in the complex relationship between obesity, inflammation and insulin resistance that are determined by whether they are classically or alternatively activated by T-helper-1 or T-helper-2 cytokines, respectively. The former leads to insulin resistance and the latter to protection against this condition. This Review discusses this crosstalk between the immune and metabolic systems. Mechanisms of macrophage activation in obesity-induced insulin resistance

Nature Clinical Practice Endocrinology & Metabolism 4, 619 (2008). doi:10.1038/ncpendmet0976

Authors: Justin I Odegaard & Ajay Chawla

]]> Mechanisms of macrophage activation in obesity-induced insulin resistance Justin I Odegaard Ajay Chawla doi:10.1038/ncpendmet0976 Nature Clinical Practice Endocrinology & Metabolism 4, 619 (2008) 2008-10-07 Nature Clinical Practice Endocrinology & Metabolism 2008-10-07 4 11 Review 619 626 Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9 http://dx.doi.org/10.1038/ncpendmet0980 Aquaporin subtypes 7 and 9 have vital roles in the control of glycerol channels in adipocytes and hepatocytes, and thereby the balance between glycerol release and uptake by adipocytes and the liver, respectively. This Review discusses the pathophysiological importance of these channels in obesity and related disorders. Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9

Nature Clinical Practice Endocrinology & Metabolism 4, 627 (2008). doi:10.1038/ncpendmet0980

Authors: Norikazu Maeda, Tohru Funahashi & Iichiro Shimomura

]]> Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9 Norikazu Maeda Tohru Funahashi Iichiro Shimomura doi:10.1038/ncpendmet0980 Nature Clinical Practice Endocrinology & Metabolism 4, 627 (2008) 2008-10-14 Nature Clinical Practice Endocrinology & Metabolism 2008-10-14 4 11 Review 627 634 Pituitary apoplexy within a macroprolactinoma http://dx.doi.org/10.1038/ncpendmet0968 Pituitary apoplexy, caused by infarction or hemorrhage within the pituitary gland, usually presents with headache, visual disturbance and decreased consciousness. The coincidence of these symptoms with those of more common medical emergencies might delay the diagnosis, as in the patient described here. The authors discuss diagnostic and management approaches for this potentially life-threatening syndrome. Pituitary apoplexy within a macroprolactinoma

Nature Clinical Practice Endocrinology & Metabolism 4, 635 (2008). doi:10.1038/ncpendmet0968

Authors: Alastair Watt, Louis Pobereskin & Bijay Vaidya

]]> Pituitary apoplexy within a macroprolactinoma Alastair Watt Louis Pobereskin Bijay Vaidya doi:10.1038/ncpendmet0968 Nature Clinical Practice Endocrinology & Metabolism 4, 635 (2008) 2008-09-16 Nature Clinical Practice Endocrinology & Metabolism 2008-09-16 4 11 Case Study 635 641 The effect of thiazolidinediones on BMD and osteoporosis http://dx.doi.org/10.1038/ncpendmet0978 The effect of thiazolidinediones on BMD and osteoporosis

Nature Clinical Practice Endocrinology & Metabolism 4, 643 (2008). doi:10.1038/ncpendmet0978

Author: Allyson K McDonough, Richard S Rosenthal, Xu Cao & Kenneth G Saag

]]> The effect of thiazolidinediones on BMD and osteoporosis Allyson K McDonough Richard S Rosenthal Xu Cao Kenneth G Saag doi:10.1038/ncpendmet0978 Nature Clinical Practice Endocrinology & Metabolism 4, 643 (2008) 2008-09-30 Nature Clinical Practice Endocrinology & Metabolism 2008-09-30 4 11 Erratum 643 643 Differentiating between body fat and lean mass—how should we measure obesity? http://dx.doi.org/10.1038/ncpendmet0999 Differentiating between body fat and lean mass—how should we measure obesity?

Nature Clinical Practice Endocrinology & Metabolism 4, E1 (2008). doi:10.1038/ncpendmet0999

Authors: Tibor Szabó, Stephan von Haehling & Wolfram Doehner

]]> Differentiating between body fat and lean mass—how should we measure obesity? Tibor Szabó Stephan von Haehling Wolfram Doehner doi:10.1038/ncpendmet0999 Nature Clinical Practice Endocrinology & Metabolism 4, E1 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Article Response E1 E1 Authors' response to “Differentiating between body fat and lean mass—how should we measure obesity?” http://dx.doi.org/10.1038/ncpendmet1000 Authors' response to “Differentiating between body fat and lean mass—how should we measure obesity?”

Nature Clinical Practice Endocrinology & Metabolism 4, E2 (2008). doi:10.1038/ncpendmet1000

Authors: Abel Romero-Corral, Francisco Lopez-Jimenez, Justo Sierra-Johnson & Virend K Somers

]]> Authors' response to “Differentiating between body fat and lean mass—how should we measure obesity?” Abel Romero-Corral Francisco Lopez-Jimenez Justo Sierra-Johnson Virend K Somers doi:10.1038/ncpendmet1000 Nature Clinical Practice Endocrinology & Metabolism 4, E2 (2008) Nature Clinical Practice Endocrinology & Metabolism 4 11 Article Response E2 E2