Clinical Pharmacology & Therapeutics http://www.nature.com/clpt/current_issue/ Nature Publishing Group en Copyright © Nature Publishing Group Clinical Pharmacology & Therapeutics 0009-9236 Copyright © Nature Publishing Group permissions@nature.com Clinical Pharmacology & Therapeutics http://www.nature.com/aj/images/logos_b_o_w/clpt.gif http://www.nature.com/clpt/ In This Issue http://dx.doi.org/10.1038/clpt.2008.225 In This Issue

Clinical Pharmacology & Therapeutics 84, 637 (December 2008). doi:10.1038/clpt.2008.225

Author:

]]> In This Issue doi:10.1038/clpt.2008.225 Clinical Pharmacology & Therapeutics 84, 637 (December 2008) Clinical Pharmacology & Therapeutics 84 6 637 637 Adolescent Pharmacology: A Pertinent Issue of Medicine as Opposed to Medicines http://dx.doi.org/10.1038/clpt.2008.206 Adolescent Pharmacology: A Pertinent Issue of Medicine as Opposed to Medicines

Clinical Pharmacology & Therapeutics 84, 639 (December 2008). doi:10.1038/clpt.2008.206

Authors: GL Kearns & M Spaulding-Barclay

]]> Adolescent Pharmacology: A Pertinent Issue of Medicine as Opposed to Medicines GL Kearns M Spaulding-Barclay doi:10.1038/clpt.2008.206 Clinical Pharmacology & Therapeutics 84, 639 (December 2008) Clinical Pharmacology & Therapeutics 84 6 639 644 Highlights http://dx.doi.org/10.1038/clpt.2008.226 Highlights

Clinical Pharmacology & Therapeutics 84, 646 (December 2008). doi:10.1038/clpt.2008.226

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]]> Highlights doi:10.1038/clpt.2008.226 Clinical Pharmacology & Therapeutics 84, 646 (December 2008) Clinical Pharmacology & Therapeutics 84 6 646 647 ASCPT News http://dx.doi.org/10.1038/clpt.2008.227 ASCPT News

Clinical Pharmacology & Therapeutics 84, 648 (December 2008). doi:10.1038/clpt.2008.227

]]> ASCPT News doi:10.1038/clpt.2008.227 Clinical Pharmacology & Therapeutics 84, 648 (December 2008) Clinical Pharmacology & Therapeutics 84 6 648 652 Adolescent Health in the United States, 2007 http://dx.doi.org/10.1038/clpt.2008.207 Adolescent Health in the United States, 2007

Clinical Pharmacology & Therapeutics 84, 653 (December 2008). doi:10.1038/clpt.2008.207

Author: ML Dreyer

]]> Adolescent Health in the United States, 2007 ML Dreyer doi:10.1038/clpt.2008.207 Clinical Pharmacology & Therapeutics 84, 653 (December 2008) Clinical Pharmacology & Therapeutics 84 6 653 654 Adolescents in Clinical Trials http://dx.doi.org/10.1038/clpt.2008.191 Adolescents in Clinical Trials

Clinical Pharmacology & Therapeutics 84, 655 (December 2008). doi:10.1038/clpt.2008.191

Authors: BG Kapogiannis & DR Mattison

]]> Adolescents in Clinical Trials BG Kapogiannis DR Mattison doi:10.1038/clpt.2008.191 Clinical Pharmacology & Therapeutics 84, 655 (December 2008) Clinical Pharmacology & Therapeutics 84 6 655 659 Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance http://dx.doi.org/10.1038/clpt.2008.140 Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance

Clinical Pharmacology & Therapeutics 84, 660 (December 2008). doi:10.1038/clpt.2008.140

Authors: AS Ray, MR Wright & GR Rhodes

]]> Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance AS Ray MR Wright GR Rhodes doi:10.1038/clpt.2008.140 Clinical Pharmacology & Therapeutics 84, 660 (December 2008) July 9, 2008 Clinical Pharmacology & Therapeutics July 9, 2008 84 6 660 660 Response to “Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance” http://dx.doi.org/10.1038/clpt.2008.169 Response to “Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance”

Clinical Pharmacology & Therapeutics 84, 661 (December 2008). doi:10.1038/clpt.2008.169

Authors: JJ Kiser & CV Fletcher

]]> Response to “Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance” JJ Kiser CV Fletcher doi:10.1038/clpt.2008.169 Clinical Pharmacology & Therapeutics 84, 661 (December 2008) August 27, 2008 Clinical Pharmacology & Therapeutics August 27, 2008 84 6 661 661 Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence http://dx.doi.org/10.1038/clpt.2008.202 Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence

Clinical Pharmacology & Therapeutics 84, 662 (December 2008). doi:10.1038/clpt.2008.202

Author: MJ Kennedy

]]> Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence MJ Kennedy doi:10.1038/clpt.2008.202 Clinical Pharmacology & Therapeutics 84, 662 (December 2008) October 29, 2008 Clinical Pharmacology & Therapeutics October 29, 2008 84 6 662 673 Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency http://dx.doi.org/10.1038/clpt.2008.185 Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency

Clinical Pharmacology & Therapeutics 84, 674 (December 2008). doi:10.1038/clpt.2008.185

Authors: MJ Kennedy, DA Davis, N Smith, A Gaedigk, RE Pearce & GL Kearns

]]> Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency MJ Kennedy DA Davis N Smith A Gaedigk RE Pearce GL Kearns doi:10.1038/clpt.2008.185 Clinical Pharmacology & Therapeutics 84, 674 (December 2008) October 8, 2008 Clinical Pharmacology & Therapeutics October 8, 2008 84 6 674 678 Multiple-Dose Pharmacodynamics and Pharmacokinetics of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Subjects http://dx.doi.org/10.1038/clpt.2008.109 Multiple-Dose Pharmacodynamics and Pharmacokinetics of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Subjects

Clinical Pharmacology & Therapeutics 84, 679 (December 2008). doi:10.1038/clpt.2008.109

Authors: R Krishna, AJ Bergman, B Jin, M Fallon, J Cote, P Van Hoydonck, T Laethem, IN Gendrano III, K Van Dyck, D Hilliard, O Laterza, K Snyder, C Chavez-Eng, R Lutz, J Chen, DM Bloomfield, M De Smet, LM Van Bortel, M Gutierrez, N Al-Huniti, K Dykstra, KM Gottesdiener & JA Wagner

]]> Multiple-Dose Pharmacodynamics and Pharmacokinetics of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Subjects R Krishna AJ Bergman B Jin M Fallon J Cote P Van Hoydonck T Laethem IN Gendrano III K Van Dyck D Hilliard O Laterza K Snyder C Chavez-Eng R Lutz J Chen DM Bloomfield M De Smet LM Van Bortel M Gutierrez N Al-Huniti K Dykstra KM Gottesdiener JA Wagner doi:10.1038/clpt.2008.109 Clinical Pharmacology & Therapeutics 84, 679 (December 2008) June 25, 2008 Clinical Pharmacology & Therapeutics June 25, 2008 84 6 679 683 Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose http://dx.doi.org/10.1038/clpt.2008.190 Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose

Clinical Pharmacology & Therapeutics 84, 684 (December 2008). doi:10.1038/clpt.2008.190

Authors: LP James, EV Capparelli, PM Simpson, L Letzig, D Roberts, JA Hinson, GL Kearns, JL Blumer & JE Sullivan

]]> Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose LP James EV Capparelli PM Simpson L Letzig D Roberts JA Hinson GL Kearns JL Blumer JE Sullivan doi:10.1038/clpt.2008.190 Clinical Pharmacology & Therapeutics 84, 684 (December 2008) October 15, 2008 Clinical Pharmacology & Therapeutics October 15, 2008 84 6 684 690 Etoposide Sensitivity Does Not Predict MLL Rearrangements or Risk of Therapy-Related Acute Myeloid Leukemia http://dx.doi.org/10.1038/clpt.2008.86 Etoposide Sensitivity Does Not Predict MLL Rearrangements or Risk of Therapy-Related Acute Myeloid Leukemia

Clinical Pharmacology & Therapeutics 84, 691 (December 2008). doi:10.1038/clpt.2008.86

Authors: J Yang, A Bogni, C Cheng, WK Bleibel, X Cai, Y Fan, W Yang, JCC Rocha, D Pei, W Liu, ME Dolan, C-H Pui & MV Relling

]]> Etoposide Sensitivity Does Not Predict MLL Rearrangements or Risk of Therapy-Related Acute Myeloid Leukemia J Yang A Bogni C Cheng WK Bleibel X Cai Y Fan W Yang JCC Rocha D Pei W Liu ME Dolan C-H Pui MV Relling doi:10.1038/clpt.2008.86 Clinical Pharmacology & Therapeutics 84, 691 (December 2008) May 28, 2008 Clinical Pharmacology & Therapeutics May 28, 2008 84 6 691 697 The Effect of Atazanavir and Atazanavir/Ritonavir on UDP-Glucuronosyltransferase Using Lamotrigine as a Phenotypic Probe http://dx.doi.org/10.1038/clpt.2008.106 The Effect of Atazanavir and Atazanavir/Ritonavir on UDP-Glucuronosyltransferase Using Lamotrigine as a Phenotypic Probe

Clinical Pharmacology & Therapeutics 84, 698 (December 2008). doi:10.1038/clpt.2008.106

Authors: DM Burger, A Huisman, N Van Ewijk, H Neisingh, P Van Uden, GA Rongen, P Koopmans & RJ Bertz

]]> The Effect of Atazanavir and Atazanavir/Ritonavir on UDP-Glucuronosyltransferase Using Lamotrigine as a Phenotypic Probe DM Burger A Huisman N Van Ewijk H Neisingh P Van Uden GA Rongen P Koopmans RJ Bertz doi:10.1038/clpt.2008.106 Clinical Pharmacology & Therapeutics 84, 698 (December 2008) June 4, 2008 Clinical Pharmacology & Therapeutics June 4, 2008 84 6 698 703 Influence of Solute Carriers on the Pharmacokinetics of CYP3A4 Probes http://dx.doi.org/10.1038/clpt.2008.94 Influence of Solute Carriers on the Pharmacokinetics of CYP3A4 Probes

Clinical Pharmacology & Therapeutics 84, 704 (December 2008). doi:10.1038/clpt.2008.94

Authors: RM Franke, SD Baker, RH Mathijssen, EG Schuetz & A Sparreboom

]]> Influence of Solute Carriers on the Pharmacokinetics of CYP3A4 Probes RM Franke SD Baker RH Mathijssen EG Schuetz A Sparreboom doi:10.1038/clpt.2008.94 Clinical Pharmacology & Therapeutics 84, 704 (December 2008) May 28, 2008 Clinical Pharmacology & Therapeutics May 28, 2008 84 6 704 709 Effects of Breast Pumping on the Pharmacokinetics and Pharmacodynamics of Ethanol During Lactation http://dx.doi.org/10.1038/clpt.2008.119 Effects of Breast Pumping on the Pharmacokinetics and Pharmacodynamics of Ethanol During Lactation

Clinical Pharmacology & Therapeutics 84, 710 (December 2008). doi:10.1038/clpt.2008.119

Authors: MY Pepino & JA Mennella

]]> Effects of Breast Pumping on the Pharmacokinetics and Pharmacodynamics of Ethanol During Lactation MY Pepino JA Mennella doi:10.1038/clpt.2008.119 Clinical Pharmacology & Therapeutics 84, 710 (December 2008) July 2, 2008 Clinical Pharmacology & Therapeutics July 2, 2008 84 6 710 714 β-Adrenergic Receptor Gene Polymorphisms and β-Blocker Treatment Outcomes in Hypertension http://dx.doi.org/10.1038/clpt.2008.139 β-Adrenergic Receptor Gene Polymorphisms and β-Blocker Treatment Outcomes in Hypertension

Clinical Pharmacology & Therapeutics 84, 715 (December 2008). doi:10.1038/clpt.2008.139

Authors: MA Pacanowski, Y Gong, RM Cooper-DeHoff, NJ Schork, MD Shriver, TY Langaee, CJ Pepine & JA Johnson

]]> β-Adrenergic Receptor Gene Polymorphisms and β-Blocker Treatment Outcomes in Hypertension MA Pacanowski Y Gong RM Cooper-DeHoff NJ Schork MD Shriver TY Langaee CJ Pepine JA Johnson doi:10.1038/clpt.2008.139 Clinical Pharmacology & Therapeutics 84, 715 (December 2008) July 9, 2008 Clinical Pharmacology & Therapeutics July 9, 2008 84 6 715 721 Pharmacogenetics of Warfarin: Development of a Dosing Algorithm for Brazilian Patients http://dx.doi.org/10.1038/clpt.2008.166 Pharmacogenetics of Warfarin: Development of a Dosing Algorithm for Brazilian Patients

Clinical Pharmacology & Therapeutics 84, 722 (December 2008). doi:10.1038/clpt.2008.166

Authors: JA Perini, CJ Struchiner, E Silva-Assunção, ISC Santana, F Rangel, EB Ojopi, E Dias-Neto & G Suarez-Kurtz

]]> Pharmacogenetics of Warfarin: Development of a Dosing Algorithm for Brazilian Patients JA Perini CJ Struchiner E Silva-Assunção ISC Santana F Rangel EB Ojopi E Dias-Neto G Suarez-Kurtz doi:10.1038/clpt.2008.166 Clinical Pharmacology & Therapeutics 84, 722 (December 2008) August 27, 2008 Clinical Pharmacology & Therapeutics August 27, 2008 84 6 722 728 Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs http://dx.doi.org/10.1038/clpt.2008.193 Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs

Clinical Pharmacology & Therapeutics 84, 729 (December 2008). doi:10.1038/clpt.2008.193

Authors: JS Barrett, JM Skolnik, B Jayaraman, D Patel & PC Adamson

]]> Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs JS Barrett JM Skolnik B Jayaraman D Patel PC Adamson doi:10.1038/clpt.2008.193 Clinical Pharmacology & Therapeutics 84, 729 (December 2008) October 15, 2008 Clinical Pharmacology & Therapeutics October 15, 2008 84 6 729 733 Personalized Therapeutics: HIV Treatment in Adolescents http://dx.doi.org/10.1038/clpt.2008.187 Personalized Therapeutics: HIV Treatment in Adolescents

Clinical Pharmacology & Therapeutics 84, 734 (December 2008). doi:10.1038/clpt.2008.187

Authors: NY Rakhmanina, EV Capparelli & JN van den Anker

]]> Personalized Therapeutics: HIV Treatment in Adolescents NY Rakhmanina EV Capparelli JN van den Anker doi:10.1038/clpt.2008.187 Clinical Pharmacology & Therapeutics 84, 734 (December 2008) October 1, 2008 Clinical Pharmacology & Therapeutics October 1, 2008 84 6 734 740 Contraceptive Availability to Adolescents: Do American Values Violate Our Most Vulnerable? http://dx.doi.org/10.1038/clpt.2008.178 Contraceptive Availability to Adolescents: Do American Values Violate Our Most Vulnerable?

Clinical Pharmacology & Therapeutics 84, 741 (December 2008). doi:10.1038/clpt.2008.178

Author: MJ Elders

]]> Contraceptive Availability to Adolescents: Do American Values Violate Our Most Vulnerable? MJ Elders doi:10.1038/clpt.2008.178 Clinical Pharmacology & Therapeutics 84, 741 (December 2008) September 17, 2008 Clinical Pharmacology & Therapeutics September 17, 2008 84 6 741 745 Government Support for Abstinence-Only-Until-Marriage Education http://dx.doi.org/10.1038/clpt.2008.188 Government Support for Abstinence-Only-Until-Marriage Education

Clinical Pharmacology & Therapeutics 84, 746 (December 2008). doi:10.1038/clpt.2008.188

Authors: K Duffy, DA Lynch & J Santinelli

]]> Government Support for Abstinence-Only-Until-Marriage Education K Duffy DA Lynch J Santinelli doi:10.1038/clpt.2008.188 Clinical Pharmacology & Therapeutics 84, 746 (December 2008) October 15, 2008 Clinical Pharmacology & Therapeutics October 15, 2008 84 6 746 748 The Adolescent With Asthma: Fostering Adherence to Optimize Therapy http://dx.doi.org/10.1038/clpt.2008.189 The Adolescent With Asthma: Fostering Adherence to Optimize Therapy

Clinical Pharmacology & Therapeutics 84, 749 (December 2008). doi:10.1038/clpt.2008.189

Authors: BL Jones & KJ Kelly

]]> The Adolescent With Asthma: Fostering Adherence to Optimize Therapy BL Jones KJ Kelly doi:10.1038/clpt.2008.189 Clinical Pharmacology & Therapeutics 84, 749 (December 2008) October 22, 2008 Clinical Pharmacology & Therapeutics October 22, 2008 84 6 749 753 CORRIGENDUM: New Imaging Approaches for Understanding Lung Cancer Response to Treatment http://dx.doi.org/10.1038/clpt.2008.199 CORRIGENDUM: New Imaging Approaches for Understanding Lung Cancer Response to Treatment

Clinical Pharmacology & Therapeutics 84, 754 (December 2008). doi:10.1038/clpt.2008.199

]]> CORRIGENDUM: New Imaging Approaches for Understanding Lung Cancer Response to Treatment doi:10.1038/clpt.2008.199 Clinical Pharmacology & Therapeutics 84, 754 (December 2008) Clinical Pharmacology & Therapeutics 84 6 754 754