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  • RESEARCH BRIEFINGS

Genetic risk variants lead to type 2 diabetes development through different pathways

The largest genome-wide association study for type 2 diabetes so far, which included several ancestry groups, led to the identification of eight clusters of genetic risk variants. The clusters capture different biological pathways that contribute to the disease, and some clusters are associated with vascular complications.

This is a summary of: Suzuki, K. et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature 627, 347–357 (2024).

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doi: https://doi.org/10.1038/d41586-024-00440-x

Figure 1 is published under a CC BY 4.0 licence.

References

  1. Ahmad, E., Lim, S., Lasmptey, R., Webb, D. R. & Davies, M. J. Lancet 400, 1803–1820 (2022).

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  2. Uffelmann, E. et al. Nature Rev. Methods Primers 1, 59 (2021).

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